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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 911528생성일: 2026년 10월 25일

1-[4-(Bromomethyl)phenyl]ethan-1-one → 6-(4-acetylbenzylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine

https://huagongshe.com/reaction/911528

반응식

참여 물질

역할이름HCID투입량
반응물1-[4-(Bromomethyl)phenyl]ethan-1-oneHCID 583785—
반응물3-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 57655979—
생성물6-(4-acetylbenzylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 57656189—

반응 단계

Use a method similar to the Example 380, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 4-acetylbenzyl bromide to give, after chromatography eluting with hexane/EtOAc (15:1), the desired intermediate as a white solid. MS (APCI+) m/z 346 (M+H−Boc)+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08022062B2
출처 데이터셋uspto-grants-2011_09
ORD IDord-a242c8b05f6d4b9497cdfd6d4ef43606
출처 메모uspto-grants-2011_09