1-Iodo-4-nitrobenzene → N-[3-(4-methylpiperazin-1-yl)propyl]-4-nitro-1-aminobenzene

HRID 912298

반응식

HRID 912298 반응식
I[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][NH2:21])[CH2:14][CH2:13]1>>[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][NH:21][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)[CH2:14][CH2:13]1

참가 물질

3

반응물 2

HCID 124951-Iodo-4-nitrobenzeneHCID 783281-(3-Aminopropyl)-4-methylpiperazine

생성물 1

HCID 21975010N-[3-(4-methylpiperazin-1-yl)propyl]-4-nitro-1-aminobenzene

실험 절차

Using 1-iodo-4-nitro-benzene (500 mg) instead of 1-bromo-3-nitro-benzene, and 3-(4-methyl-piperazin-1-yl)-propylamine (379 mg) instead of morpholine, in the same manner as Step A in Example 1-D-105, the desired compound was obtained (432 mg, 77%).

출처 및 근거

ORD 기록
ord-e4660a3f5af040859863afab87d5fd01
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022205B2

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