Hydrochloric Acid → HCID 67416461, 화합물

반응식

[Si]([O:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH2:14][C@H:13]([NH:17]C(=O)OC(C)(C)C)[C:12]1=[O:25])(C(C)(C)C)(C)C.O1CCOCC1.[ClH:32]>>[ClH:32].[NH2:17][C@H:13]1[CH2:14][CH2:15][CH2:16][N:11]([CH2:10][CH2:9][OH:8])[C:12]1=[O:25]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane

HCID 57736559HCID 57736559, 화합물

생성물 1

HCID 67416461HCID 67416461, 화합물수율 100%

실험 절차

(S)-tert-Butyl 1-(2-(tert-butyldimethylsilyloxy)ethyl)-2-oxopiperidin-3-ylcarbamate (Example 13; 100 mg, 0.268 mmol) was dissolved in 4M hydrogen chloride in dioxane (2 mL, 8.0 mmol) and the reaction mixture was allowed to stir at ambient temperature for 72 hours. The reaction mixture was concentrated to yield (S)-3-amino-1-(2-hydroxyethyl)piperidin-2-one hydrochloride (52 mg, 100%) which was taken on to the next step without further purification.