Acetazolamide → 5-Amino-1,3,4-thiadiazole-2-sulfonamide

HRID 912575

반응식

HRID 912575 반응식
CC([NH:4][C:5]1[S:9][C:8]([S:10]([NH2:13])(=[O:12])=[O:11])=[N:7][N:6]=1)=O.[OH-].[K+]>Cl>[NH2:4][C:5]1[S:9][C:8]([S:10]([NH2:13])(=[O:12])=[O:11])=[N:7][N:6]=1

참가 물질

4

반응물 2

HCID 1986AcetazolamideHCID 14797Potassium Hydroxide

생성물 1

HCID 847245-Amino-1,3,4-thiadiazole-2-sulfonamide수율 72.9%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
100 °C

실험 절차

Acetazolamide (2.03 g, 9.13 mmol) was combined with 1N HCl (20 mL) and then heated at 100° C. The initial suspension became a clear solution within 3h. After cooling to 0° C. the reaction mixture was carefully neutralized by the addition of solid KOH. Upon standing precipitates had formed and were collected by filtration. The solids were dried under high vacuum to afford 5-amino-[1,3,4]thiadiazole-2-sulfonic acid amide (1.2 g, 70%) as a colorless solid; 1H NMR (DMSO-d6): δ 8.06 (s, 2H), 7.82 (s, 2H). Acetazolamide (2.03 g, 9.13 mmol) was combined with 1 N HCl (20 mL) and then heated at 100° C. The initial suspension became a clear solution within 3h. After cooling to 0° C. A.

후처리

  1. customwithin 3h
  2. temperatureAfter cooling to 0° C. the reaction mixture
  3. customUpon standing precipitates
  4. customhad formed
  5. filtrationwere collected by filtration
  6. customThe solids were dried under high vacuum

출처 및 근거

ORD 기록
ord-5d84373e38b24444bdf252184c130f7c
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026237B2

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