Formic Acid → HCID 67252161, 화합물

HRID 912581노트

반응식

HRID 912581 반응식
C[O:2][C:3]([C:5]1[C:9]([CH3:10])=[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]([F:20])([F:19])[F:18])[N:7]([CH3:21])[CH:6]=1)=[O:4].[OH-].[Na+].C(O)=O>CO.O>[CH3:21][N:7]1[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]([F:19])([F:20])[F:18])=[C:9]([CH3:10])[C:5]([C:3]([OH:4])=[O:2])=[CH:6]1

참가 물질

6

반응물 3

HCID 284Formic AcidHCID 14798Sodium HydroxideHCID 67253051HCID 67253051, 화합물

생성물 1

HCID 67252161HCID 67252161, 화합물수율 90.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of 1,4-dimethyl-5-(2-trifluoromethyl-phenyl)-1H-pyrrole-3-carboxylic acid methyl ester (2.5 g, 8.4 mmol) in MeOH (20 mL) was added 4N NaOH (10 mL) and the mixture was heated to reflux overnight. Evaporation of solvent gave a solid, which was re-dissolved in water. The solution was acidified with formic acid. The resulting solids were collected by filtration, washed with water and then dried under high vacuum to afford the title compound as an off-white solid (2.15 g, 90%). MS (ES): 284 (MH+).

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux overnight
  3. customEvaporation of solvent
  4. customgave a solid, which
  5. filtrationThe resulting solids were collected by filtration
  6. washwashed with water
  7. customdried under high vacuum

출처 및 근거

ORD 기록
ord-0ed749bdbc9f41ab8b66d1d039d816ae
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026237B2

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