Hydrochloric Acid → 1-(3-Chloropyridin-2-yl)piperazine hydrochloride

HRID 912764

반응식

HRID 912764 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO.CCOC(C)=O>[ClH:20].[Cl:20][C:19]1[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:15][CH:16]=[CH:17][CH:18]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 11630777Tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate

생성물 1

HCID 204550741-(3-Chloropyridin-2-yl)piperazine hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of the ester from step (a) above (2.98 g, 10 mmol) in MeOH (5 mL) was added saturated solution of hydrogen chloride in EtOAc (50 mL) and the mixture was stirred at room temperature for 4 h. The solvent was removed in vacuo, and the residue was washed with EtOAc and dried in the air to provide the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 198 (M+1).

후처리

  1. customThe solvent was removed in vacuo
  2. washthe residue was washed with EtOAc
  3. customdried in the air

출처 및 근거

ORD 기록
ord-c93b2a1e0f454847a3ddf9c15a5091aa
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026241B2

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