Water → 6-(2-ethyl-1,3-dioxolan-2-yl)-1-(4-(2-naphthyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)hexan-1-ol

HRID 913059노트

반응식

HRID 913059 반응식
[CH2:1]([C:3]1([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([C:15]2[N:16]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])[CH:17]=[C:18]([C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=3)[N:19]=2)=[O:14])[O:7][CH2:6][CH2:5][O:4]1)[CH3:2].[BH4-].[Na+].O>CCO>[CH2:1]([C:3]1([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]([C:15]2[N:16]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:36])([CH3:37])[CH3:35])[CH:17]=[C:18]([C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=3)[N:19]=2)[OH:14])[O:4][CH2:5][CH2:6][O:7]1)[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 673819946-(2-ethyl-1,3-dioxolan-2-yl)-1-(4-(2-naphthyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)hexan-1-one

생성물 1

HCID 673820876-(2-ethyl-1,3-dioxolan-2-yl)-1-(4-(2-naphthyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)hexan-1-ol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of the ketone F1 in EtOH (0.04 M solution) at 0° C. was added NaBH4 (2.0 eq.) and the mixture was stirred for 1 hr. Water was slowly added and the aqueous phase was extracted with EtOAc. The combined organic extracts were dried (MgSO4) and solvents were removed under reduced pressure. The crude product was used without purification in the next step. MS (ES) C30H44N2O4Si requires: 525, found: 526 (M+H)+.

후처리

  1. extractionthe aqueous phase was extracted with EtOAc
  2. dry with materialThe combined organic extracts were dried (MgSO4) and solvents
  3. customwere removed under reduced pressure
  4. customThe crude product was used without purification in the next step

출처 및 근거

ORD 기록
ord-a5cd1468753140538d775661d14cb41c
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026265B2

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