Hydrochloric Acid → HCID 16739068, 화합물

반응식

C(OC([NH:8][C:9]1[C:10]([NH:20][C:21]([C:23]2[CH:43]=[CH:42][C:26]([CH2:27][NH:28][C:29](=[O:41])[O:30][C:31]3[CH:40]=[CH:39][C:38]4[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=4)[CH:32]=3)=[CH:25][CH:24]=2)=[O:22])=[N:11][N:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:13]=1)=O)(C)(C)C.Cl>C(OCC)(=O)C.O1CCOCC1>[NH2:8][C:9]1[C:10]([NH:20][C:21]([C:23]2[CH:43]=[CH:42][C:26]([CH2:27][NH:28][C:29](=[O:41])[O:30][C:31]3[CH:40]=[CH:39][C:38]4[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=4)[CH:32]=3)=[CH:25][CH:24]=2)=[O:22])=[N:11][N:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:13]=1

참가 물질

실험 절차

To a solution of 2-naphthyl {4-[({4-[(tert-butoxycarbonyl)amino]-1-phenyl-1H-pyrazol-3-yl}amino)carbonyl]benzyl}carbamate (approximately 5 mg) in ethyl acetate (1 mL) was added 4M HCl in dioxane (1 mL). The reaction was stirred at ambient temperature for 16 hours. Evaporation in vacuo gave the title compound as a white solid. 1H NMR (600 MHz, CD3OD) δ 8.44 (s, 1H), 8.07 (d, J=8.2 Hz, 2H), 7.87 (t, J=8.5 Hz, 2H), 7.82 (d, J=7.9 Hz, 1H), 7.79 (d, J=8.8 Hz, 2H), 7.52 (m, 7H), 7.37 (t, J=7.3 Hz, 1H), 7.28 (dd, J=8.8, 2.1 Hz, 1H), 4.50 (s, 2H); ESIMS calcd 478.2 (M++H), found 478.1 (M++H).