Stavudine → HCID 86625622, 화합물

HRID 913264

반응식

HRID 913264 반응식
[C@@H:1]1([N:8]2[CH:16]=[C:14]([CH3:15])[C:12](=[O:13])[NH:11][C:9]2=[O:10])[O:7][C@H:4]([CH2:5][OH:6])[CH:3]=[CH:2]1.[CH3:17][N:18]1[C:23](=[O:24])[N:22]([CH3:25])[CH2:21][CH2:20][CH2:19]1>CC(C)=O>[CH3:15][C:14]1[C:12](=[O:13])[NH:11][C:9](=[O:10])[N:8]([C@@H:1]2[O:7][C@H:4]([CH2:5][OH:6])[CH:3]=[CH:2]2)[CH:16]=1.[CH3:17][N:18]1[C:23](=[O:24])[N:22]([CH3:25])[CH2:21][CH2:20][CH2:19]1

참가 물질

4

반응물 2

HCID 18283StavudineHCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-

생성물 1

HCID 86625622HCID 86625622, 화합물수율 87.5%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
56 °C

실험 절차

Crude Stavudine (25 g, 97.7% pure, 0.1116 mole), DMPU (37.5 g, 1.5 parts) are added to acetone (50 ml) and heated to 56° C. for dissolution. The obtained solution is stirred for 15 min. at 56° C. and cooled to 6-8° C. The precipitated product is filtered, washed with acetone and dried to give 34.4 g of Stavudine DMPU solvate (87.5%) with a chromatographic purity 99.93%.

후처리

  1. temperaturecooled to 6-8° C
  2. filtrationThe precipitated product is filtered
  3. washwashed with acetone
  4. customdried

출처 및 근거

ORD 기록
ord-2bdc41f217664607a37266af142ffb4a
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026356B2

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