Stavudine DMPU → Stavudine

HRID 913265

반응식

HRID 913265 반응식
[CH3:1][C:2]1[C:8](=[O:9])[NH:7][C:5](=[O:6])[N:4]([C@@H:10]2[O:14][C@H:13]([CH2:15][OH:16])[CH:12]=[CH:11]2)[CH:3]=1.CN1C(=O)N(C)CCC1>O>[C@@H:10]1([N:4]2[CH:3]=[C:2]([CH3:1])[C:8](=[O:9])[NH:7][C:5]2=[O:6])[O:14][C@H:13]([CH2:15][OH:16])[CH:12]=[CH:11]1

참가 물질

3

반응물 1

HCID 86625622Stavudine DMPU

생성물 1

HCID 18283Stavudine수율 66.82%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
2.5 °C

실험 절차

Stavudine DMPU solvate (20 g, 0.057 mole) is dissolved in water (20 ml) at 55° C. and the solution is allowed cooling on its own for an hour to crystallize. The mixture is further cooled on 0-5° C. for 2 hrs. The precipitated product is filtered, washed with acetone and dried to give 8.5 g (66.82%) of pure white crystalline Stavudine. HPLC results are given in Table-2

후처리

  1. temperaturethe solution is allowed cooling on its own for an hour
  2. customto crystallize
  3. filtrationThe precipitated product is filtered
  4. washwashed with acetone
  5. customdried

출처 및 근거

ORD 기록
ord-c22b27eb05fb4b52934752f5d42be106
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026356B2

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