Bromomethylcyclopropane → 1-(Cyclopropylmethyl)-2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 913551

반응식

HRID 913551 반응식
[CH3:1][CH:2]([CH3:19])[CH2:3][C:4]1[NH:5][C:6]2[C:11]([CH:12]=1)=[C:10]([C:13]([F:16])([F:15])[F:14])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=2.Br[CH2:21][CH:22]1[CH2:24][CH2:23]1>>[CH:22]1([CH2:21][N:5]2[C:6]3[C:11](=[C:10]([C:13]([F:16])([F:14])[F:15])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=3)[CH:12]=[C:4]2[CH2:3][CH:2]([CH3:19])[CH3:1])[CH2:24][CH2:23]1

참가 물질

3

반응물 2

HCID 81503BromomethylcyclopropaneHCID 674051962-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

생성물 1

HCID 674054851-(Cyclopropylmethyl)-2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

실험 절차

Synthesized as described in Example 4 using 2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile and (bromomethyl)cyclopropane. 1H NMR (400 MHz, CDCl3) δ 7.50 (d, J=9.2 Hz, 1H), 7.48 (d, J=9.2 Hz, 1H), 6.56 (d, J=1.7 Hz, 1H), 4.05 (d, J=6.6 Hz, 2H), 2.67 (t, J=7.1 Hz, 2H), 2.07 (m, 1H), 1.15 (m, 1H), 1.03 (d, J=6.6 Hz, 6H), 0.58 (m, 2H), 0.35 (m, 2H); MS (ES) m/z 321 (M+1).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-63b19bdefda640469401dd5a0929cbb7
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026262B2

연결된 노트

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