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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 913696생성일: 2026년 10월 26일

3-(Chloromethyl)-5-[2-fluoro-5-(trifluoromethyl)phenyl]-1,2,4-oxadiazole → 1-({5-[2-Fluoro-5-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913696

반응식

참여 물질

역할이름HCID투입량
반응물3-(Chloromethyl)-5-[2-fluoro-5-(trifluoromethyl)phenyl]-1,2,4-oxadiazoleHCID 5311734—
반응물2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 53309346—
생성물1-({5-[2-Fluoro-5-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 86620695—

반응 단계

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 3-(chloromethyl)-5-[2-fluoro-5-(trifluoromethyl)phenyl]-1,2,4-oxadiazole: 1H NMR (400 MHz, CDCl3) δ 8.33 (m, 1H), 7.85 (m, 1H), 7.69 (d, J=8.6 Hz, 1H), 7.56 (d, J=8.6 Hz, 1H), 7.39 (d, J=9.3 Hz, 1H), 6.65 (s, 1H), 5.50 (s, 2H), 2.68 (s, 3H); MS (ES) m/z 469 (M+1).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08026262B2
출처 데이터셋uspto-grants-2011_09
ORD IDord-4e3fe2e0297243dd95e14ed9555c4ede
출처 메모uspto-grants-2011_09