Hydrochloric Acid → HCID 178431468, 화합물

HRID 914796노트

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HRID 914796 반응식
[CH3:1][S:2]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[C:10]([CH3:25])=[C:11]2[N:16]([CH:17]=1)[N:15]=[CH:14][N:13]=[C:12]2[O:18]C1C=CC=CC=1)(=[O:4])=[O:3].Cl>C(O)C>[CH3:1][S:2]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[C:10]([CH3:25])=[C:11]2[N:16]([CH:17]=1)[N:15]=[CH:14][N:13]=[C:12]2[OH:18])(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 225088806-(3-Methanesulfonyl-propoxy)-5-methyl-4-phenoxypyrrolo[2,1-f][1,2,4]triazine

생성물 1

HCID 178431468HCID 178431468, 화합물수율 95%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
80 °C

실험 절차

A mixture of 6-(3-methanesulfonyl-propoxy)-5-methyl-4-phenoxypyrrolo[2,1-f][1,2,4]triazine (1.1 g, 3.04 mmol), HCl (1N, 20 mL) and ethanol (20 mL) was heated at 80° C. for 3 h. The volatiles were removed in vacuo. The white solid was triturated with diethyl ether/hexane (2:1) to afford 6-(3-methanesulfonyl-propoxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-ol (820 mg, 95%) as a white solid MS: (M+H)+=286.

후처리

  1. customThe volatiles were removed in vacuo
  2. customThe white solid was triturated with diethyl ether/hexane (2:1)

출처 및 근거

ORD 기록
ord-d96108be183e494fa85c3449c35f0e9f
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265113B2

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