Tetrahydrofuran → HCID 22248434, 화합물

HRID 914832노트

반응식

HRID 914832 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[NH2:22])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:23]1CC[CH2:25][CH2:24]1>C(OC(=O)C)(=O)C.C(N(CC)CC)C>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[NH:22][C:24](=[O:23])[CH3:25])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 2

HCID 8028TetrahydrofuranHCID 22248383tert-Butyl 4-[(2-aminophenoxy)methyl]piperidine-1-carboxylate

생성물 1

HCID 22248434HCID 22248434, 화합물수율 100%

시약·촉매·용매 2

HCID 7918Acetic Anhydride용매HCID 8471Triethylamine용매

실험 절차

After dissolving 400 mg of 1-(tert-butoxycarbonyl)-4-(2-aminophenoxymethyl)piperidine in 10 ml of tetrahydrofuran, 0.15 ml of acetic anhydride and 0.24 ml of triethylamine were added and the mixture was stirred overnight at room temperature. The reaction solution was filtered with silica gel and NH silica gel. The solvent was distilled off under reduced pressure to obtain the title compound (459 mg, 100% yield).

후처리

  1. additionwere added
  2. filtrationThe reaction solution was filtered with silica gel and NH silica gel
  3. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-938502070349403f9459dafcdf8c91cc
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265108B2

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