Trifluoroacetic acid → [2-(3,4-Dihydro-1H-isoquinolin-2-yl)ethyl]-(7-nitro-3,4-dihydro-2H-naphthalen-1-ylidene)amine

참여 물질

역할	이름	HCID	투입량
반응물	Trifluoroacetic acid	HCID 6422	—
반응물	7-Nitro-1-tetralone	HCID 38445	—
반응물	2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)ethan-1-amine	HCID 40742	—
용매	Toluene	HCID 1140	—
용매	Ethyl Acetate	HCID 8857	—
생성물	[2-(3,4-Dihydro-1H-isoquinolin-2-yl)ethyl]-(7-nitro-3,4-dihydro-2H-naphthalen-1-ylidene)amine	HCID 58958206	94%

반응 조건

온도	130 °C

반응 단계

To a solution of 36 (964 mg, 5.48 mmol) and 7-nitro-3,4-dihydro-2H-naphthalen-1-one (95) (1.05 g, 5.48 mmol) in toluene (30 mL) was added a catalytic amount of TFA. The reaction was heated at 130° C. overnight before it was allowed to cool to room temperature and diluted with EtOAc (100 mL). The organic solution was sequentially washed with saturated NaHCO3 (aq. 100 mL), brine (100 mL), dried over Na2SO4, and concentrated to give 96 as a brown oil (1.8 g, 94%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07265122B2
출처 데이터셋	uspto-grants-2007_09
ORD ID	ord-875f97cde2c04a11a6c7244706e0814f
출처 메모	uspto-grants-2007_09