反应详情

温度

130 °C

To a solution of 36 (964 mg, 5.48 mmol) and 7-nitro-3,4-dihydro-2H-naphthalen-1-one (95) (1.05 g, 5.48 mmol) in toluene (30 mL) was added a catalytic amount of TFA. The reaction was heated at 130° C. overnight before it was allowed to cool to room temperature and diluted with EtOAc (100 mL). The organic solution was sequentially washed with saturated NaHCO3 (aq. 100 mL), brine (100 mL), dried over Na2SO4, and concentrated to give 96 as a brown oil (1.8 g, 94%).

1. temperatureto cool to room temperature
2. washThe organic solution was sequentially washed with saturated NaHCO3 (aq. 100 mL), brine (100 mL)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated