Lithium Hydroxide → {6-[1-methyl-5-(4-trifluoromethoxy-phenyl)-1H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid
반응식
C([O:3][C:4](=[O:34])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:16][C:17]3[CH:21]=[C:20]([C:22]4[CH:27]=[CH:26][C:25]([O:28][C:29]([F:32])([F:31])[F:30])=[CH:24][CH:23]=4)[N:19]([CH3:33])[N:18]=3)[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[CH3:33][N:19]1[C:20]([C:22]2[CH:23]=[CH:24][C:25]([O:28][C:29]([F:32])([F:31])[F:30])=[CH:26][CH:27]=2)=[CH:21][C:17]([CH2:16][O:15][C:12]2[CH:13]=[C:14]3[C:9]([CH:8]=[CH:7][N:6]3[CH2:5][C:4]([OH:34])=[O:3])=[CH:10][CH:11]=2)=[N:18]1참가 물질
3
실험 절차
In analogy to the procedure described for example 1 f], {6-[1-methyl-5-(4-trifluoromethoxy-phenyl)-1H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain {6-[1-methyl-5-(4-trifluoromethoxy-phenyl)-1H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid as colorless solid.
출처 및 근거
- ORD 기록
- ord-17eb28fa75194f5bbcf9099d630f22b0
- 출처 데이터셋
- uspto-grants-2007_09