Thionyl Chloride → 5-chloromethyl-1-(2,2,2-trifluoro-ethyl)-3-(4-trifluoromethoxy-phenyl)-1H-pyrazole

HRID 915474노트

반응식

HRID 915474 반응식
[F:1][C:2]([F:23])([F:22])[CH2:3][N:4]1[C:8]([CH2:9]O)=[CH:7][C:6]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)=[N:5]1.S(Cl)([Cl:26])=O>C(Cl)(Cl)Cl>[Cl:26][CH2:9][C:8]1[N:4]([CH2:3][C:2]([F:23])([F:22])[F:1])[N:5]=[C:6]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)[CH:7]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 86600629[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol

생성물 1

HCID 866006325-chloromethyl-1-(2,2,2-trifluoro-ethyl)-3-(4-trifluoromethoxy-phenyl)-1H-pyrazole

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

In analogy to the procedure described for example 1 b], [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol (example 15 b]) was reacted with thionyl chloride in chloroform to yield 5-chloromethyl-1-(2,2,2-trifluoro-ethyl)-3-(4-trifluoromethoxy-phenyl)-1H-pyrazole as colorless oil.

출처 및 근거

ORD 기록
ord-f323e755176f448a9fc7f82c3ec3bb96
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265149B2

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