2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → N-Ethyl-N'-(8-methyl-5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)urea
반응식
[S:1]1[C:12]2[C:11]3[NH:10][CH:9]=[CH:8][C:7]=3[CH2:6][CH2:5][C:4]=2[N:3]=[C:2]1[NH:13][C:14]([NH:16][CH2:17][CH3:18])=[O:15].[C:19](C1C(=O)C(Cl)=C(Cl)C(=O)C=1C#N)#N>C1(C)C=CC=CC=1>[CH2:17]([NH:16][C:14]([NH:13][C:2]1[S:1][C:12]2[C:11]3[N:10]([CH3:19])[CH:9]=[CH:8][C:7]=3[CH2:6][CH2:5][C:4]=2[N:3]=1)=[O:15])[CH3:18]참가 물질
4
반응 조건
- 온도
- 45 °C
실험 절차
To a suspension of N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N′-ethylurea in toluene is added DDQ (1.1 eq.). The reaction mixture is stirred at about 45° C. for about 4 hrs. The reaction mixture is pumped down and the crude material is purified by preparative HPLC.
후처리
- customthe crude material is purified by preparative HPLC
출처 및 근거
- ORD 기록
- ord-2df8a4191bd44591b7d0af914e3af49b
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07091227B2
반응 노트
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