Piperazine → N-(6-Bromo-1,3-benzothiazol-2-yl)-N'-(3-piperazinopropyl)urea

HRID 9162

반응식

HRID 9162 반응식
[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15]Cl)=[O:11])[S:8][C:4]=2[CH:3]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>C1COCC1.CCO>[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)=[O:11])[S:8][C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 21985572N-(6-bromo-1,3-benzothiazol-2-yl)-N'-(3-chloropropyl)urea

생성물 1

HCID 21985562N-(6-Bromo-1,3-benzothiazol-2-yl)-N'-(3-piperazinopropyl)urea

시약·촉매·용매 1

HCID 21873804Tetrahydrofuran ethanol용매

반응 조건

온도
55 °C

실험 절차

To a mixture of N-(6-bromo-1,3-benzothiazol-2-yl)-N′-(3-chloropropyl)urea (100 mg, 0.287 mmol) in THF/EtOH (0.50/0.25 mL) was added piperazine (247 mg, 2.87 mmol). The reaction mixture was heated to about 55° C. for about 16 hrs. The crude reaction mixture was pumped down and purified by flash chromatography on SiO2.

후처리

  1. customThe crude reaction mixture
  2. custompurified by flash chromatography on SiO2

출처 및 근거

ORD 기록
ord-8cc7371e38f3460581b5e22886eb5510
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091227B2

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