Hydrochloric Acid → 1-Ethylcarbonyl-4-oxohomopiperidine

HRID 917062노트

반응식

HRID 917062 반응식
[O:1]=[C:2]1[CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl.[C:10]([O-:13])([O-])=O.[K+].[K+].ClC(O[CH2:20][CH3:21])=O>C1COCC1>[CH2:20]([C:10]([N:5]1[CH2:6][CH2:7][CH2:8][C:2](=[O:1])[CH2:3][CH2:4]1)=[O:13])[CH3:21]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 10928Ethyl chloroformateHCID 11430Potassium CarbonateHCID 1501891Azepan-4-one

생성물 1

HCID 186757361-Ethylcarbonyl-4-oxohomopiperidine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a cold (0° C.) stirred solution of 4-oxohomopiperidine.HCl (0.6 g, 4.05 mmol), K2CO3 (0.615 g, 4.46 mmol) in anhydrous THF (10 mL) will be ethyl chloroformate (0.44 mL, 4.05 mmol) dropwise. The reaction was warmed to RT for 2 hrs then quenched with H2O, extracted with EtOAc, and the organic layer dried over Na2SO4. Pure 1-ethylcarbonyl-4-oxohomopiperidine will be isolated via silica gel flash chromatography.

후처리

  1. customthen quenched with H2O
  2. extractionextracted with EtOAc
  3. dry with materialthe organic layer dried over Na2SO4

출처 및 근거

ORD 기록
ord-b80128a1be7e48e6b0fd10cc8840b5a2
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07271176B2

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