Ethyl isocyanate → 1-(6-Bromo-2-benzothiazolyl)-3-ethylurea

HRID 9171

반응식

HRID 9171 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH2:9])[S:8][C:4]=2[CH:3]=1.[CH2:12]([N:14]=[C:15]=[O:16])[CH3:13].C(N(CC)CC)C>CN(C=O)C>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH:9][C:15]([NH:14][CH2:12][CH3:13])=[O:16])[S:8][C:4]=2[CH:3]=1

참가 물질

5

반응물 3

HCID 8022Ethyl isocyanateHCID 8471TriethylamineHCID 851492-Benzothiazolamine, 6-bromo-

생성물 1

HCID 219855641-(6-Bromo-2-benzothiazolyl)-3-ethylurea

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

About 0.75 g of 6-bromo-1,3-benzothiazol-2-amine (crude) is dissolved in about 15 mL DMF. About 0.5 mL of ethylisocyanate is added followed by about 0.9 mL triethylamine and the solution is heated to about 80° C. under good agitation. The solution is allowed to stir for about 4 hours then cooled to RT. The solvent is removed in vacuo and the solids are washed well with ether. The product is further purified by column chromatography.

후처리

  1. temperaturethen cooled to RT
  2. customThe solvent is removed in vacuo
  3. washthe solids are washed well with ether
  4. customThe product is further purified by column chromatography

출처 및 근거

ORD 기록
ord-0c31608d9ad04d16b80f61e52ee18c38
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091227B2

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