반응식
[C:1]([C:3]1[CH:17]=[CH:16][C:6]2[N:7]=[C:8]([NH:10][C:11]([NH:13][CH2:14][CH3:15])=[O:12])[S:9][C:5]=2[CH:4]=1)#[N:2].Cl.NO.C(=O)([O-])[O-:22].[Na+].[Na+]>>[CH2:14]([NH:13][C:11]([NH:10][C:8]1[S:9][C:5]2[CH:4]=[C:3]([C:1]([NH2:2])=[O:22])[CH:17]=[CH:16][C:6]=2[N:7]=1)=[O:12])[CH3:15]참가 물질
4
실험 절차
About 1 g of N-(6-cyano-1,3-benzothiazol-2-yl)-N′-ethylurea was charged into about 30 mL of aqueous alkanol. Added about 0.6 g hydroxylamine hydrochloride and about 0.45 g sodium carbonate then heated to reflux. The solution was refluxed for about 4–8 hours then cooled to room temperature. The precipitate was recovered by filtration and washed well with water. LC/MS indicated a mixture of two products identified as the following after further purification by preparative HPLC:
후처리
- temperaturethen heated to reflux
- temperatureThe solution was refluxed for about 4–8 hours
- filtrationThe precipitate was recovered by filtration
- washwashed well with water
- additiona mixture of two products
- customfollowing after further purification by preparative HPLC
출처 및 근거
- ORD 기록
- ord-42e183c75b274ca58d1e4a2d590f020c
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07091227B2
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