4-Methylmorpholine → N-(7-Methoxy-4-phenyl-thiazolo[5,4-c]pyridin-2-yl)-2-methyl-isonicotinamide

HRID 917466노트

반응식

HRID 917466 반응식
Cl.[CH3:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][N:11]=1)[C:6]([OH:8])=O.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CN1CCOCC1.[CH3:43][O:44][C:45]1[C:46]2[N:59]=[C:58]([NH2:60])[S:57][C:47]=2[C:48]([C:51]2[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=2)=[N:49][CH:50]=1>C1COCC1>[CH3:43][O:44][C:45]1[C:46]2[N:59]=[C:58]([NH:60][C:6](=[O:8])[C:5]3[CH:9]=[CH:10][N:11]=[C:3]([CH3:2])[CH:4]=3)[S:57][C:47]=2[C:48]([C:51]2[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=2)=[N:49][CH:50]=1

참가 물질

6

반응물 4

HCID 79724-MethylmorpholineHCID 27628242-methylpyridine-4-carboxylic Acid HydrochlorideHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 860384747-Methoxy-4-phenyl-thiazolo[5,4-c]pyridin-2-ylamine

생성물 1

HCID 11566998N-(7-Methoxy-4-phenyl-thiazolo[5,4-c]pyridin-2-yl)-2-methyl-isonicotinamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

From 2-methyl-isonicotinic acid hydrochloride, HATU and N-methylmorpholine in THF, then treatment with 7-methoxy-4-phenyl-thiazolo[5,4-c]pyridin-2-ylamine. ES-MS m/e (%): 377 (M+H+, 100).

출처 및 근거

ORD 기록
ord-b655e909b88546349790a5d2de430fa7
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07273865B2

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