Iodine chloride → 3-Chloro-4-amino-5-iodobenzylamine

HRID 917546

반응식

HRID 917546 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[NH2:10])[CH2:5][NH2:6].[I:11]Cl>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([I:11])[C:9]=1[NH2:10])[CH2:5][NH2:6]

참가 물질

4

반응물 2

HCID 24640Iodine chlorideHCID 218806504-(Aminomethyl)-2-chloroaniline

생성물 1

HCID 589629913-Chloro-4-amino-5-iodobenzylamine수율 42%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 3-Chloro-4-aminobenzylamine (200 mg, 1.28 mmol) in methanol (5 mL) was added iodine monochloride (230 mg, 1.42 mmol). The mixture was stirred for 1 hour, then purified by HPLC to give 3-chloro-4-amino-5-iodobenzylamine (150 mg, 42%).

후처리

  1. custompurified by HPLC

출처 및 근거

ORD 기록
ord-d1b5d861910c4a4885fceaa14a0d2bed
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07273882B2

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