(S)-Ethyl 3-amino-3-phenylpropanoate → (R)-Ethyl 3-amino-3-phenylpropanoate

반응식

[CH2:1]([O:3][C:4](=[O:14])[CH2:5][C@@H:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[NH2:7])[CH3:2].[Na].[K]>>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][C@H:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[NH2:7])[CH3:2]

참가 물질

반응물 2

HCID 915085(S)-Ethyl 3-amino-3-phenylpropanoate

HCID 16211683Potassium alloy, nonbase, K,Na

생성물 1

HCID 915086(R)-Ethyl 3-amino-3-phenylpropanoate수율 93.1%

반응 조건

온도: 20 °C

실험 절차

In a 25 ml flask, 13.0 g of D-β-phenylalanine ethyl ester was charged under nitrogen, and sodium-potassium alloy (Na : K = 56 : 44 by weight) (0.1 g) was added thereto. The mixture was stirred at 20°C for 3 hours. The reaction mixture was treated as in Example 11 to give 12.1 g of racemic β-phenylalanine ethyl ester. B.P. 95° to 96°C/0.6 mmHg. [α]D25 -0.1° (neat).

후처리

additionThe reaction mixture was treated as in Example 11

출처 및 근거

ORD 기록: ord-d96040b264dc47d38633722070ebf611
출처 데이터셋: uspto-grants-1976_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US03970700

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