Hydrochloric Acid → N-{2-[(Oxan-2-yl)oxy]ethyl}urea

HRID 918376노트

반응식

HRID 918376 반응식
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][NH2:10].[N-:11]=[C:12]=[O:13].[K+].Cl>O>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][NH:10][C:12]([NH2:11])=[O:13]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10820667HCID 10820667, 화합물HCID 11051572Potassio isocyanate

생성물 1

HCID 12850116N-{2-[(Oxan-2-yl)oxy]ethyl}urea수율 92%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 33.2 g of 2-(tetrahydropyran-2-yloxy) ethylamine, 50 g of ice, and a solution of 35 g of potassium isocyanate in 80 ml of water is stirred well as 45.6 ml of 5N hydrochloric acid (cooled to -40°C) is added in one portion. The resulting solution is refluxed for 90 minutes, cooled, and extracted with four 150 ml portions of chloroform. The chloroform extract is dried and evaporated in vacuo to give 39.6 g of oil.

후처리

  1. additionis added in one portion
  2. temperatureThe resulting solution is refluxed for 90 minutes
  3. temperaturecooled
  4. extractionextracted with four 150 ml portions of chloroform
  5. extractionThe chloroform extract
  6. customis dried
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-042a42538bc24372870c2e91c821de2c
출처 데이터셋
uspto-grants-1976_07
특허 번호
US03971772

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