Hydrochloric Acid → 21-Chloro-11beta,17-dihydroxy-16alpha-(2-mesyloxyethoxy)pregna-1,4-diene-3,20-dione

HRID 918417노트

반응식

HRID 918417 반응식
[Cl:1][CH2:2][C:3](=[O:30])[C@:4]1([OH:29])[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C@@H:19]([OH:23])[CH2:20]2)[C@:16]2([CH3:17])[C:11](=[CH:12][C:13](=[O:24])[CH:14]=[CH:15]2)[CH2:10][CH2:9]3)[CH2:6][C@H:5]1[O:25][CH2:26][CH2:27][OH:28].[CH3:31][S:32](Cl)(=[O:34])=[O:33].Cl>N1C=CC=CC=1>[Cl:1][CH2:2][C:3](=[O:30])[C@:4]1([OH:29])[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C@@H:19]([OH:23])[CH2:20]2)[C@:16]2([CH3:17])[C:11](=[CH:12][C:13](=[O:24])[CH:14]=[CH:15]2)[CH2:10][CH2:9]3)[CH2:6][C@H:5]1[O:25][CH2:26][CH2:27][O:28][S:32]([CH3:31])(=[O:34])=[O:33]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 31297Methanesulfonyl chlorideHCID 8673376021-Chloro-11beta,17-dihydroxy-16alpha-(2-hydroxyethoxy)pregna-1,4-diene-3,20-dione

생성물 1

HCID 8673376121-Chloro-11beta,17-dihydroxy-16alpha-(2-mesyloxyethoxy)pregna-1,4-diene-3,20-dione

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 21-chloro-11β,17-dihydroxy-16α-(2-hydroxyethoxy)pregna-1,4-diene-3,20-dione (7.6 mmoles) in 30 ml of pyridine is cooled to 0°C and 1 ml of methanesulfonyl chloride is added. After 2 hours the mixture is poured into cold dilute hydrochloric acid and extracted with chloroform. The chloroform solution is dried and evaporated in vacuo to yield the title compound.

후처리

  1. extractionextracted with chloroform
  2. dry with materialThe chloroform solution is dried
  3. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-ce70573a3aed435a8288f2b2e7890bd9
출처 데이터셋
uspto-grants-1976_07
특허 번호
US03971773

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