Bromine → 4-Bromo-5-hydroxy-1-[(1-methylethyl)amino]-9,10-anthracenedione

HRID 918540노트

반응식

HRID 918540 반응식
[CH:1]([NH:4][C:5]1[C:18]2[C:17](=[O:19])[C:16]3[C:11](=[C:12]([OH:20])[CH:13]=[CH:14][CH:15]=3)[C:10](=[O:21])[C:9]=2[CH:8]=[CH:7][CH:6]=1)([CH3:3])[CH3:2].[Br:22]Br>Cl>[CH:1]([NH:4][C:5]1[C:18]2[C:17](=[O:19])[C:16]3[C:11](=[C:12]([OH:20])[CH:13]=[CH:14][CH:15]=3)[C:10](=[O:21])[C:9]=2[C:8]([Br:22])=[CH:7][CH:6]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 24408BromineHCID 215211751-Isopropylamino-5-hydroxy-anthraquinone2회

생성물 1

HCID 215121524-Bromo-5-hydroxy-1-[(1-methylethyl)amino]-9,10-anthracenedione

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

If the 12.9 parts of 1-isopropylamino-5-hydroxy-anthraquinone obtained in Example 3 are dissolved in 130 parts of 30% strength hydrochloric acid, 9.5 parts of bromine are added dropwise at room temperature, and the mixture is further stirred at room temperature or at elevated temperature (up to 40°) until at most 5% of 1-isopropylamino-5-hydroxy-anthraquinone can still be detected chromatographically in a sample which has been withdrawn, then 15.95 parts of 1-isopropylamino-5-hydroxy-4-bromanthraquinone are obtained after pouring out into 300 parts of water and further working up as described in (a). The quality of this product is only slightly better than that of the product obtained according to Example 4a.

후처리

  1. additionare added dropwise at room temperature
  2. customhas been withdrawn

출처 및 근거

ORD 기록
ord-c64feda6af1d4e598e5c72bc530e0fcf
출처 데이터셋
uspto-grants-1976_07
특허 번호
US03971812

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