Thionyl Chloride → 2-Bromo-p-chlorophenylacetyl chloride

HRID 918577

반응식

HRID 918577 반응식
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=O.S(Cl)([Cl:15])=O>>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([Cl:15])=[O:12]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 218285032-Bromo-4-chlorophenylacetic acid

생성물 1

HCID 197942342-Bromo-p-chlorophenylacetyl chloride수율 88.2%

실험 절차

28.3g (0.113 mol) of 2-bromo-p-chlorophenylacetic acid was mixed with 26.9g (0.226 mol) of thionylchloride and the mixture was refluxed for 2.5 hours. After the excess thionylchloride had been distilled off, the reaction mixture was distilled under reduced pressure to give 26.7g of 2-bromo-p-chlorophenylacetyl chloride as yellow-orange oil. (b.p. 148° - 152°C/15 mmHg)

후처리

  1. temperaturethe mixture was refluxed for 2.5 hours
  2. distillationAfter the excess thionylchloride had been distilled off
  3. distillationthe reaction mixture was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-0a9b9b78ae254be2987c42d7e132ee20
출처 데이터셋
uspto-grants-1976_07
특허 번호
US03971828

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