Sodium Hydroxide → 3-Amino-4-phenoxy-5-sulfamoylbenzoic acid

HRID 918654

반응식

HRID 918654 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:18](=[O:21])(=[O:20])[NH2:19])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:5](N)=[O:6].[OH-:22].[Na+]>>[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:18](=[O:21])(=[O:20])[NH2:19])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:5]([OH:22])=[O:6]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 215060743-Amino-4-phenoxy-5-sulphamyl-benzamide

생성물 1

HCID 1199273-Amino-4-phenoxy-5-sulfamoylbenzoic acid

실험 절차

A mixture of 3-amino-4-phenoxy-5-sulphamyl-benzamide (1 g) and 1N sodium hydroxide (20 ml) was refluxed for 1 hour. After cooling, the 3-amino-4-phenoxy-5-sulphamyl-benzoic acid was precipitated from the reaction mixture by addition of 4N hydrochloric acid until pH 2.5. After several recrystallizations from aqueous ethanol and drying, the compound was obtained with a melting point of 252°-253°C.

후처리

  1. temperaturewas refluxed for 1 hour
  2. temperatureAfter cooling
  3. customthe 3-amino-4-phenoxy-5-sulphamyl-benzoic acid was precipitated from the reaction mixture by addition of 4N hydrochloric acid until pH 2.5
  4. customAfter several recrystallizations from aqueous ethanol
  5. customdrying
  6. customthe compound was obtained with a melting point of 252°-253°C.

출처 및 근거

ORD 기록
ord-16b81e99edb841e085ac215f84a24b02
출처 데이터셋
uspto-grants-1976_07
특허 번호
US03971819

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