Propyl Gallate → Thyroxine

HRID 918791

반응식

HRID 918791 반응식
C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.C(O)[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O.[CH:36]1[C:37]([CH2:54][C@H:55]([NH2:59])[C:56]([O-:58])=[O:57])=[CH:38][C:39]([I:53])=[C:40]([O:43][C:44]2[CH:45]=[C:46]([I:52])[C:47]([OH:51])=[C:48]([I:50])[CH:49]=2)[C:41]=1[I:42].O.[Na+].C(OCCC)(=O)C1C=C(O)C(O)=C(O)C=1>O>[CH:38]1[C:37]([CH2:54][C@H:55]([NH2:59])[C:56]([OH:58])=[O:57])=[CH:36][C:41]([I:42])=[C:40]([O:43][C:44]2[CH:49]=[C:48]([I:50])[C:47]([OH:51])=[C:46]([I:52])[CH:45]=2)[C:39]=1[I:53]

참가 물질

6

반응물 4

HCID 4947Propyl GallateHCID 5988SucroseHCID 6251MannitolHCID 23667619Levothyroxine sodium monohydrate

생성물 1

HCID 5819Thyroxine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The microcrystalline cellulose, mannitol, and sucrose were screened or milled and then blended with levothyroxine sodium for about 6 minutes. Acacia, dissolved in water, and propyl gallate, dissolved in alcohol, were added over about 10 minutes to granulate the mixture. The wet granulation was dried at a temperature below 60° C. until the moisture content was less than about 4%. The dried granulation was sized by passing it through a mill, and then blended with the additional ingredients listed in the table below using conventional mixing equipment.

후처리

  1. custommilled
  2. additionwere added over about 10 minutes
  3. customThe wet granulation was dried at a temperature below 60° C. until the moisture content

출처 및 근거

ORD 기록
ord-0bd877d47e864390a12d8cb9751902d4
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09271951B2

연결된 노트

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