Methanol → HCID 68154716, 화합물

HRID 918883노트

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HRID 918883 반응식
[O:1]=[C:2]1[N:7]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)[CH:6]=[C:5]([C:13]([O:15]C)=[O:14])[CH:4]=[CH:3]1.[OH-].[Li+].[CH3:19]O>O>[CH3:19][C:6]1[N:7]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)[C:2](=[O:1])[CH:3]=[CH:4][C:5]=1[C:13]([OH:15])=[O:14]

참가 물질

5

반응물 3

HCID 887MethanolHCID 3939Lithium HydroxideHCID 14920282HCID 14920282, 화합물

생성물 1

HCID 68154716HCID 68154716, 화합물수율 73%

시약·촉매·용매 1

HCID 962Water용매

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온도
75 °C

실험 절차

After 680 mg (2.88 mmol) of methyl 6-oxo-1-(2-thiazolyl)-1,6-dihydro-3-pyridinecarboxylate was dissolved in 12 mL of methanol and 4 mL of water, 207 mg (8.64 mmol) of lithium hydroxide was added to the solution. Afterward, the resulting reaction solution was stirred at about 75° C. for 5 hours. After termination of the reaction was determined by liquid chromatography, the solvent was removed in vacuo, and aqueous HCl was then added to the reaction solution to titrate until pH 2 was reached. The resulting solid compound was filtrated to obtain a target compound (Actual yield: 466 mg, Percent yield: 73%).

후처리

  1. customAfterward, the resulting reaction solution
  2. customthe solvent was removed in vacuo, and aqueous HCl
  3. additionwas then added to the reaction solution
  4. filtrationThe resulting solid compound was filtrated
  5. customto obtain a target compound (Actual yield: 466 mg, Percent yield: 73%)

출처 및 근거

ORD 기록
ord-dadd78f5ea8446dba1df2c7da090f62a
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09271976B2

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