1-[4'-(5-tert-Butoxycarbonylamino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester → HCID 67959556, 화합물

HRID 919087노트

반응식

HRID 919087 반응식
[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[CH:22]=[N:23][N:24]([CH3:34])[C:25]=4[NH:26]C(OC(C)(C)C)=O)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]>Cl>[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[CH:22]=[N:23][N:24]([CH3:34])[C:25]=4[NH2:26])=[CH:17][CH:16]=3)=[CH:13][CH:14]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

참가 물질

3

반응물 1

HCID 679596791-[4'-(5-tert-Butoxycarbonylamino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

생성물 1

HCID 67959556HCID 67959556, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

1-[4′-(5-tert-Butoxycarbonylamino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester (0.49 g, 1.1 mmol) was dissolved in HCl (4 N in dioxane, 3 mL) and stirred at room temperature for 30 minutes. The reaction was concentrated to dryness to yield the title compound as the hydrochloride salt.

후처리

  1. concentrationThe reaction was concentrated to dryness

출처 및 근거

ORD 기록
ord-996835e451394706855624d75dbf0d33
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09272990B2

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