2-Boc-Amino-3-iodo-4-chloropyridine → 4-Chloro-3-iodopyridin-2-amine

HRID 919299노트

반응식

HRID 919299 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8]C(=O)OC(C)(C)C)[C:3]=1[I:16]>Br>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1[I:16]

참가 물질

3

반응물 1

HCID 598528862-Boc-Amino-3-iodo-4-chloropyridine

생성물 1

HCID 229365964-Chloro-3-iodopyridin-2-amine

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매

반응 조건

온도
100 °C

실험 절차

The solution of tert-butyl 4-chloro-3-iodopyridin-2-ylcarbamate (3.2 g, 9 mmol) in HBr (48%, 15 mL) was allowed to stir at 100° C. for 1 h. The reaction mixture was concentrated and the resulting residue was neutralized with aqueous Na2CO3, extracted with EtOAc (2×25 mL), dried over Na2SO4, filtered and concentrated to used in next step directly without further purification. LC/MS m/z=255.19 [M+H]+

후처리

  1. concentrationThe reaction mixture was concentrated
  2. extractionextracted with EtOAc (2×25 mL)
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customto used in next step directly without further purification

출처 및 근거

ORD 기록
ord-8fddd853c3c747f1be988788d1a28ff7
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09273033B2

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