Methanol → 2-Fluoro-4-(2-hydroxyethyl)phenol
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10](O)=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8].B.CO>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][OH:11])[CH:5]=[CH:6][C:7]=1[OH:8]참가 물질
5
실험 절차
To a solution of 2-(3-fluoro-4-hydroxyphenyl)acetic acid (9.8 g, 57.6 mmol) in THF (500 mL) was added dropwise 57.6 mL of borane (10M in Me2S) at room temperature. The reaction mixture was stirred at room temperature for 12 hours. The reaction mixture was added to CH3OH and was concentrated under reduced pressure. The residue was partitioned between EtOAc (800 mL) and water (100 mL). The organic layer was dried and concentrated to dryness to give the title product (8.5 g, 76%).
후처리
- concentrationwas concentrated under reduced pressure
- customThe residue was partitioned between EtOAc (800 mL) and water (100 mL)
- customThe organic layer was dried
- concentrationconcentrated to dryness
출처 및 근거
- ORD 기록
- ord-96fe742a6f6944548b58cbf634560b95
- 출처 데이터셋
- uspto-grants-2016_03
- 특허 번호
- US09273054B2
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