1,4-Dioxane → 3-{2-[4-(2,6-Dichloro-benzyloxy)-phenyl]-morpholin-4-yl}-propionic acid hydrochloride
반응식
C([O:5][C:6](=[O:31])[CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][O:12][CH:11]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]3[C:28]([Cl:29])=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:30])=[CH:17][CH:16]=2)[CH2:10]1)(C)(C)C.O1CCOCC1>Cl>[ClH:29].[Cl:29][C:28]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:30])[C:23]=1[CH2:22][O:21][C:18]1[CH:17]=[CH:16][C:15]([CH:11]2[O:12][CH2:13][CH2:14][N:9]([CH2:8][CH2:7][C:6]([OH:31])=[O:5])[CH2:10]2)=[CH:20][CH:19]=1참가 물질
4
실험 절차
3-{2-[4-(2,6-Dichloro-benzyloxy)-phenyl]-morpholin-4-yl}-propionic acid tert-butyl ester (0.59 g; 1.27 mmol) was dissolved in a 4M solution of HCl in 1,4-dioxane (6.33 mL, 25.30 mmol) and stirred overnight at RT. Subsequently, the solvent was removed in vacuo and the residue treated with iPr2O, the precipitate was collected by filtration and dried overnight under reduced pressure to afford 3-{2-[4-(2,6-Dichloro-benzyloxy)-phenyl]-morpholin-4-yl}-propionic acid hydrochloride (0.50 g). 1H NMR (400 MHz, DMSO-d6) δ ppm 2.88-2.97 (2 H, m) 3.11 (1 H, t, J=11.7 Hz) 3.15-3.23 (1 H, m) 3.30-3.43 (2 H, m) 3.49 (1 H, d, J=12.0 Hz) 3.55-3.64 (1 H, m) 4.01-4.20 (2 H, m) 4.88 (1 H, d, J=12.0 Hz) 5.24 (2 H, s) 7.04-7.12 (2 H, m) 7.35 (2 H, d, J=8.7 Hz) 7.40-7.49 (1 H, m) 7.49-7.56 (2 H, m).