Hydrazine hydrate (1:1) → 7-(pyridin-4-yl)thieno[3,2-d]pyridazin-4(5H)-one

HRID 920902노트

반응식

HRID 920902 반응식
[C:1]([C:9]1[S:10][CH:11]=[CH:12][C:13]=1[C:14]([O:16]CC)=O)(=O)[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[NH2:19][NH2:20].O>CCO>[N:5]1[CH:6]=[CH:7][C:2]([C:1]2[C:9]3[S:10][CH:11]=[CH:12][C:13]=3[C:14](=[O:16])[NH:19][N:20]=2)=[CH:3][CH:4]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 86683117Ethyl 2-isonicotinoylthiophene-3-carboxylate

생성물 1

HCID 866831187-(pyridin-4-yl)thieno[3,2-d]pyridazin-4(5H)-one수율 85.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The mixture of ethyl 2-isonicotinoylthiophene-3-carboxylate (200 mg, 0.77 mmol) from example 2.2 in NH2NH2.H2O (2 mL) and EtOH (10 mL) was stirred at room temperature for 30 min. The mixture was filtered and the solid dried to obtain the title compound (150 mg, 85.1% yield).

후처리

  1. filtrationThe mixture was filtered
  2. customthe solid dried

출처 및 근거

ORD 기록
ord-1486e61f12834859b396a2cbe561b3cc
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09273068B2

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