Sodium Hydroxide → HCID 86683166, 화합물

HRID 920948노트

반응식

HRID 920948 반응식
C([NH:4]/[N:5]=[CH:6]/[C:7]1[CH:17]=[N:16][CH:15]=[C:14]([Cl:18])[C:8]=1[C:9](OCC)=[O:10])(=O)C.[OH-].[Na+].C([O-])(O)=O.[Na+]>O1CCOCC1>[Cl:18][C:14]1[C:8]2[C:9](=[O:10])[NH:4][N:5]=[CH:6][C:7]=2[CH:17]=[N:16][CH:15]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 516892Sodium BicarbonateHCID 140606546HCID 140606546, 화합물

생성물 1

HCID 86683166HCID 86683166, 화합물수율 16.9%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

(E)-ethyl 3-((2-acetylhydrazono)methyl)-5-chloroisonicotinate (220 mg, 0.816 mmol) and aq. NaOH solution (3.26 mg, 0.082 mmol, 2 molar) in 5 mL of dioxane were stirred in a microwave at 165° C. for 60 min. Then the reaction mixture was basified by addition of aq. NaHCO3 and extracted with DCM. The organic phase was washed with brine, dried and concentrated. The crude title compound was purified by chromatography (eluent: DCM/methanol) to give 25 mg (16.88%) of the title compound as beige solid.

후처리

  1. extractionextracted with DCM
  2. washThe organic phase was washed with brine
  3. customdried
  4. concentrationconcentrated
  5. customThe crude title compound was purified by chromatography (eluent: DCM/methanol)

출처 및 근거

ORD 기록
ord-c902341448284337a4735ac2bbe08a13
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09273068B2

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