Thionyl Chloride → N-(3-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide

HRID 923188노트

반응식

HRID 923188 반응식
[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=O.S(Cl)(Cl)=O.[N:16]1([C:21]2[CH:22]=[C:23]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=2)[NH2:24])[CH:20]=[CH:19][N:18]=[CH:17]1.C(N(C(C)C)CC)(C)C>C(Cl)Cl>[N:16]1([C:21]2[CH:22]=[C:23]([NH:24][C:5](=[O:7])[C:4]3[CH:8]=[CH:9][C:10]([CH3:11])=[C:2]([I:1])[CH:3]=3)[CH:25]=[C:26]([C:28]([F:30])([F:31])[F:29])[CH:27]=2)[CH:20]=[CH:19][N:18]=[CH:17]1

참가 물질

6

반응물 4

HCID 24386Thionyl ChlorideHCID 81531DiisopropylethylamineHCID 6216403-Iodo-4-methylbenzoic acidHCID 442226373-(1H-Imidazol-1-YL)-5-(trifluoromethyl)aniline

생성물 1

HCID 44222638N-(3-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide수율 84.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 3-Iodo-4-methylbenzoic acid (3.07 g, 0.0117 mol) was added thionyl chloride (10 mL) and refluxed for 2 h. The excess thionyl chloride was carefully removed and the resulting acid chloride was dried in vacuo for 2 h. The residue was then dissolved in DCM (anhydrous, 25 mL) and cooled on ice. To the cooled solution was added 3-(1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 5 (3.46 g, 0.0152 mol) in DCM followed by the dropwise addition of diisopropylethylamine (8.2 mL, 0.047 mol). This was stirred at ambient temperature for 21 h. The white solid that separated was filtered and washed with water and dried to provide 4.65 g of product. Additional product could be obtained from the filtrate following concentration and purification by silica gel flash chromatography in EtOAc/hexanes.

후처리

  1. temperaturerefluxed for 2 h
  2. customThe excess thionyl chloride was carefully removed
  3. dry with materialthe resulting acid chloride was dried in vacuo for 2 h
  4. dissolutionThe residue was then dissolved in DCM (anhydrous, 25 mL)
  5. temperaturecooled on ice
  6. customThe white solid that separated
  7. filtrationwas filtered
  8. washwashed with water
  9. customdried

출처 및 근거

ORD 기록
ord-66b157b0a398411db831b43bf9a376c5
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09278971B2

반응 노트

불러오는 중…