Acetic Anhydride → 1-Acetyl-1H-indazole-5-carboxylic acid

HRID 923309노트

반응식

HRID 923309 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]([OH:12])=[O:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[C:13](OC(=O)C)(=[O:15])[CH3:14]>CC(O)=O.CCCCCC>[C:13]([N:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]([OH:12])=[O:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1)(=[O:15])[CH3:14]

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 42484541H-Indazole-5-carboxylic acid

생성물 1

HCID 675623731-Acetyl-1H-indazole-5-carboxylic acid수율 78.5%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 8058Hexane용매

반응 조건

온도
80 °C

실험 절차

To a solution of 1H-indazole-5-carboxylic acid (8.6 g, 53.04 mmol) in AcOH (200 ml) was added acetic anhydride (16.2 g), and the reaction was stirred for 2.5 h at 80° C. The resulting solution was diluted with n-hexane (400 ml). The solids were collected by filtration and washed with hexane (5×100 ml) to afford 1-acetyl-1H-indazole-5-carboxylic acid as an orange solid (8.5 g, 78%).

후처리

  1. filtrationThe solids were collected by filtration
  2. washwashed with hexane (5×100 ml)

출처 및 근거

ORD 기록
ord-3a3bb6951d4d49e3a588653a86cb29b4
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09278973B2

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