Isopropanol → HCID 89906961, 화합물

HRID 924000노트

반응식

HRID 924000 반응식
[Br:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=1)=[O:8].Cl.[NH2:24][CH2:25][CH2:26][OH:27].CC(O)C.CCN(C(C)C)C(C)C>O>[Br:1][C:2]1[C:3]([NH:24][CH2:25][CH2:26][OH:27])=[N:4][CH:5]=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=1)=[O:8]

참가 물질

6

반응물 4

HCID 3776IsopropanolHCID 74819Ethanolamine HydrochlorideHCID 81531DiisopropylethylamineHCID 867025955-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide

생성물 1

HCID 89906961HCID 89906961, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 12.2, 0.5 g, 1.264 mmol), 2-aminoethanol hydrochloride (0.123 g, 1.896 mmol), iPrOH (4 mL) and DIPEA (0.442 mL, 0.327 g, 2.53 mmol) were subjected to MW irradiation at 140° C. for 2 h. The vial was cooled to RT and the RM was poured into water (100 mL) and the resulting precipitate was collected by filtration. The obtained solid was washed with water (50 mL) and dried to afford the title compound without further purification. LC-MS (Condition 6) tR=1.14 min, m/z=419.8 [M+H]+.

후처리

  1. customwere subjected to MW irradiation at 140° C. for 2 h
  2. filtrationthe resulting precipitate was collected by filtration
  3. washThe obtained solid was washed with water (50 mL)
  4. customdried

출처 및 근거

ORD 기록
ord-92137534bb504ee7bfa715a73df54a02
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09278981B2

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