Diisopropylethylamine → Ethylbis(propan-2-yl)amine hydrochloride

HRID 924008노트

반응식

HRID 924008 반응식
[Br:1][C:2]1[C:3]([Cl:22])=[N:4][CH:5]=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=1)=[O:8].[CH3:23][NH:24][CH2:25][CH2:26][CH2:27][OH:28].[CH3:29][CH2:30][N:31]([CH:35]([CH3:37])[CH3:36])[CH:32]([CH3:34])[CH3:33]>CC(O)C>[Br:1][C:2]1[C:3]([N:24]([CH2:25][CH2:26][CH2:27][OH:28])[CH3:23])=[N:4][CH:5]=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=1)=[O:8].[CH3:29][CH2:30][N:31]([CH:35]([CH3:37])[CH3:36])[CH:32]([CH3:34])[CH3:33].[ClH:22]

참가 물질

6

반응물 3

HCID 81531DiisopropylethylamineHCID 101489863-(Methylamino)-1-propanolHCID 867025955-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide

생성물 2

HCID 10997398Ethylbis(propan-2-yl)amine hydrochlorideHCID 899063685-bromo-6-((3-hydroxypropyl)(methyl)amino)-N-(4-(trifluoromethoxy)phenyl)nicotinamide

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 12.2, 237 mg, 0.60 mmol), 3-(methylamino)propan-1-ol (64 mg, 0.72 mmol), iPrOH (2.4 mL) and DIPEA (0.205 mL, 0.155 g, 1.2 mmol) were subjected to MW irradiation at 140° C. for 3 h. The vial was cooled to RT and the RM was evaporated to dryness under reduced pressure. No further purification was required to afford the title compound in an equimolar mixture with DIPEA hydrochloride. LC-MS (Condition 5) tR=1.18 min, m/z=448.0 [M+H]+, m/z=446.0 [M−H]−.

후처리

  1. customwere subjected to MW irradiation at 140° C. for 3 h
  2. customthe RM was evaporated to dryness under reduced pressure
  3. customNo further purification

출처 및 근거

ORD 기록
ord-c67f6c83708f43728cf52cebc9672a9c
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09278981B2

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