Hydrochloric Acid → (3S,4S)-4-Aminopyrrolidin-3-ol dihydrochloride

HRID 924123노트

반응식

[NH2:1][C@@H:2]1[C@@H:6]([OH:7])[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.CCO.[ClH:18]>>[ClH:18].[ClH:18].[NH2:1][C@H:2]1[CH2:3][NH:4][CH2:5][C@@H:6]1[OH:7]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 104654571-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine

생성물 1

HCID 69959682(3S,4S)-4-Aminopyrrolidin-3-ol dihydrochloride

실험 절차

(3S,4S)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate (0.3 g, 1.439 mmol) in 1.25 M HCl 1.25 M in EtOH (11.51 mL, 14.39 mmol) was stirred for 24 h at RT. The white suspension was evaporated to dryness under reduced pressure and the residue was suspended in MeOH (10 mL) and evaporated again to afford the title compound.

후처리

customThe white suspension was evaporated to dryness under reduced pressure
customevaporated again

출처 및 근거

ORD 기록: ord-f55e85da7c6f42ddb636bea58c38c01a
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09278981B2

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