Chlorodiisopropylphosphine → HCID 178424813, 화합물

HRID 925037노트

반응식

[C:1]([C:5]1[CH:21]=[CH:20][C:8]([C:9]([NH:11][C:12]2[C:17]([CH3:18])=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:19])=[NH:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C([Li])CCC.Cl[P:28]([CH:32]([CH3:34])[CH3:33])[CH:29]([CH3:31])[CH3:30]>>[C:1]([C:5]1[CH:21]=[CH:20][C:8]([C:9]([NH:11][C:12]2[C:13]([CH3:19])=[CH:14][CH:15]=[CH:16][C:17]=2[CH3:18])=[N:10][P:28]([CH:32]([CH3:34])[CH3:33])[CH:29]([CH3:31])[CH3:30])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

반응물 3

HCID 538967Chlorodiisopropylphosphine

HCID 178418339Butyllithium

HCID 178424805HCID 178424805, 화합물

생성물 1

HCID 178424813HCID 178424813, 화합물

실험 절차

Procedure as described for NP Amidine I using the following amounts: 1.40 g of 4-t-butyl-N1-(2,6-dimethylphenyl)benzamidine (Amidine IV, 5.0 mmol), 2.50 mL of 2.0 M butyllithium (5.0 mmol), 0.80 mL chlorodiisopropylphosphine (5.0 mmol). After filtration to remove lithium chloride and removal of solvent, a slightly cloudy yellow oil was isolated (2.04 g, 100%).

후처리

filtrationAfter filtration
customto remove
customlithium chloride and removal of solvent
customa slightly cloudy yellow oil was isolated (2.04 g, 100%)

출처 및 근거

ORD 기록: ord-6f42fdb073a644d6847b34095e301433
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09283555B2

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