Chlorodiisopropylphosphine → HCID 178425659, 화합물

HRID 925040

반응식

[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11][C:12](=[NH:20])[C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1)([CH3:4])([CH3:3])[CH3:2].C([Li])CCC.Cl[P:27]([CH:31]([CH3:33])[CH3:32])[CH:28]([CH3:30])[CH3:29]>>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11][C:12](=[N:20][P:27]([CH:31]([CH3:33])[CH3:32])[CH:28]([CH3:30])[CH3:29])[C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

반응물 3

HCID 538967Chlorodiisopropylphosphine

HCID 178418339Butyllithium

HCID 178425629HCID 178425629, 화합물

생성물 1

HCID 178425659HCID 178425659, 화합물

실험 절차

Procedure as described for NP Amidine I using the following amounts: 1.33 g of N1-(2-tert-butylphenyl)-4-methylbenzamidine (Amidine VI, 5.0 mmol), 2.50 mL of 2.0 M butyllithium (5.0 mmol), 0.80 mL chlorodiisopropylphosphine (5.0 mmol). After filtration to remove lithium chloride and removal of solvent, a yellow semi-solid was isolated (1.9 g, 100%).

후처리

filtrationAfter filtration
customto remove
customlithium chloride and removal of solvent
customa yellow semi-solid was isolated (1.9 g, 100%)

출처 및 근거

ORD 기록: ord-85c27c368e1d44bda7eca0942ba92614
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09283555B2

연결된 노트

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