Chlorodiisopropylphosphine → HCID 178460690, 화합물

HRID 925042

반응식

[C:1]([C:5]1[CH:23]=[CH:22][C:8]([C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([CH3:21])([CH3:20])[CH3:19])=[NH:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C([Li])CCC.Cl[P:30]([CH:34]([CH3:36])[CH3:35])[CH:31]([CH3:33])[CH3:32]>>[C:1]([C:5]1[CH:23]=[CH:22][C:8]([C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([CH3:21])([CH3:20])[CH3:19])=[N:10][P:30]([CH:34]([CH3:36])[CH3:35])[CH:31]([CH3:33])[CH3:32])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

반응물 3

HCID 538967Chlorodiisopropylphosphine

HCID 178418339Butyllithium

HCID 178440935HCID 178440935, 화합물

생성물 1

HCID 178460690HCID 178460690, 화합물

실험 절차

Procedure as described for NP Amidine I using the following amounts: 1.54 g of 4-tert-butyl-N1-(2-tert-butylphenyl)benzamidine (Amidine VII, 5.0 mmol), 2.50 mL of 2.0 M butyllithium (5.0 mmol), 0.80 mL chlorodiisopropylphosphine (5.0 mmol). After filtration to remove lithium chloride and removal of solvent, a yellow semi-solid was isolated (1.9 g, 100%).

후처리

filtrationAfter filtration
customto remove
customlithium chloride and removal of solvent
customa yellow semi-solid was isolated (1.9 g, 100%)

출처 및 근거

ORD 기록: ord-a7d2b1ae01704f778ef8d11870c35a07
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09283555B2

연결된 노트

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