Hydrochloric Acid → Methyl 2-(4-isopropoxyphenyl)acetate

HRID 9251

반응식

HRID 9251 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.C([O-])([O-])=O.[Cs+].[Cs+].Br[CH:20]([CH3:22])[CH3:21].Cl>CN(C=O)C>[CH3:21][CH:20]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=1)[CH3:22]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 63582-BromopropaneHCID 10796Cesium carbonateHCID 518900Benzeneacetic acid, 4-hydroxy-, methyl ester

생성물 1

HCID 525538Methyl 2-(4-isopropoxyphenyl)acetate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Methyl (4-hydroxyphenyl)acetate (1.0 g, 1.0 eq), Cs2CO3 (2.15 g, 1.1 eq) and 2-bromopropane (0.565 mL. 1.0 eq) were combined in 100 ml DMF at room temperature. The mixture was stirred overnight. The suspension was poured into 50 mL 1 N HCl and extracted with ethyl acetate. The organic phase was separated and washed with water followed by sodium bicarbonate. The organic phase was dried over sodium sulfate and the solvent was evaporated to give an oil. The resulting oil was chromatographed on silica gel using hexanes and ethyl acetate (95:5) to give methyl (4-(1-methylethoxy)phenyl)acetate.

후처리

  1. extractionextracted with ethyl acetate
  2. customThe organic phase was separated
  3. washwashed with water
  4. dry with materialThe organic phase was dried over sodium sulfate
  5. customthe solvent was evaporated
  6. customto give an oil
  7. customThe resulting oil was chromatographed on silica gel

출처 및 근거

ORD 기록
ord-7592862b4de4400099977859206fead8
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091230B2

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