Ethanol → HCID 67608342, 화합물

HRID 925289노트

반응식

HRID 925289 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]#[N:10])[N:6]=[C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:4]=1.C([O-])=O.[NH4+].C(O)C>O.[OH-].[Pd+2].[OH-].[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][NH2:10])[N:6]=[C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:4]=1

참가 물질

6

반응물 3

HCID 702EthanolHCID 2723923Ammonium formateHCID 135867984-Methoxy[2,2′-bipyridine]-6-carbonitrile

생성물 1

HCID 67608342HCID 67608342, 화합물

시약·촉매·용매 2

HCID 86707187HCID 86707187, 화합물촉매HCID 962Water용매

반응 조건

온도
27 °C

실험 절차

A mixture of 4-Methoxy-[2,2′]bipyridinyl-6-carbonitrile (1.0 g, 4.73 mmol), Palladium hydroxide-Pd 20%-50% in water (0.66 g, excess), ammonium formate (1.5 g, excess) and ethanol (60 mL) was stirred at 27° C. for 2 hours. The reaction was then filtered thorough celite, washed with methanol (150 mL) and dichloromethane (150 mL) and the organic phase evaporated to dryness affording C-(4-Methoxy-[2,2′]bipyridinyl-6-yl)-methylamine as an orange oil (0.80 g, 45%, in a ratio 72 to 28 product vs. byproduct).

후처리

  1. filtrationThe reaction was then filtered thorough celite
  2. washwashed with methanol (150 mL) and dichloromethane (150 mL)
  3. customthe organic phase evaporated to dryness

출처 및 근거

ORD 기록
ord-10b15ff6da5b48f09413dff1e52b33f7
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09284296B2

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