(R)-3-Pyrrolidinol → (3R)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]pyrrolidin-3-ol

HRID 925607노트

반응식

HRID 925607 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[N:14]2[N:15]=[C:16](Cl)[CH:17]=[CH:18][C:13]2=[N:12][CH:11]=1.[NH:20]1[CH2:24][CH2:23][C@@H:22]([OH:25])[CH2:21]1>C(O)CCC>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[N:14]2[N:15]=[C:16]([N:20]3[CH2:24][CH2:23][C@@H:22]([OH:25])[CH2:21]3)[CH:17]=[CH:18][C:13]2=[N:12][CH:11]=1

참가 물질

4

반응물 2

HCID 2759337(R)-3-PyrrolidinolHCID 71491928HCID 71491928, 화합물

생성물 1

HCID 71145051(3R)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]pyrrolidin-3-ol

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

150 mg (0.56 mmol) 3-(1-benzofur-2-yl)-6-chloroimidazo[1,2-b]pyridazine and 206.2 mg (1.67 mmol) (3R)-pyrrolidin-3-ol in 5.0 mL butan-1-ol were stirred 72 h at 150° C. The solvent was removed. The residue was purified by HPLC to yield 23 mg (13%).

후처리

  1. customThe solvent was removed
  2. customThe residue was purified by HPLC
  3. customto yield 23 mg (13%)

출처 및 근거

ORD 기록
ord-95422946872e478b86496e944c9c4e70
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09284319B2

반응 노트

불러오는 중…